Investigators discovered that adults with Down syndrome had been roughly thrice extra more likely to die from COVID-19 than the overall inhabitants. This elevated threat was particularly obvious within the fifth decade of life: A 40-year-old with Down syndrome had the same threat of dying from COVID-19 as somebody 30 years older within the normal inhabitants.
The examine was revealed in The Lancet’s Scientific Medication.
“Our outcomes, that are primarily based on greater than 1,000 COVID-19 distinctive sufferers with Down syndrome, present that people with Down syndrome typically have extra extreme signs at hospitalization and expertise excessive charges of lung issues related to elevated mortality,” stated Anke Huels, an assistant professor of epidemiology at Emory College’s Rollins Faculty of Public Well being, and the examine’s first writer. “These outcomes have implications for preventive and medical administration of COVID-19 sufferers with Down syndrome and emphasize the necessity to prioritize people with Down syndrome for vaccination.”
Down syndrome is a genetic situation sometimes attributable to the trisomy—or having an additional copy—of chromosome 21. This further copy adjustments how a child’s physique and mind develop, which may trigger each psychological and bodily challenges.
To gather knowledge for the examine, T21RS COVID-19 Initiative launched a global survey of clinicians and caregivers of people with Down syndrome contaminated with COVID-19 between April and October 2020. Survey respondents had been primarily from Europe, the US, Latin America and India. (The survey was accessible in English, Spanish, French, Italian, Portuguese, German, Bengali, Hindi and Mandarin).
“We’re delighted to see that, partly primarily based on our findings, the CDC included Down syndrome within the checklist of ‘high-risk medical situations,’ which can prioritize these with this genetic situation for vaccination,” stated co-author Alberto Costa, professor of pediatrics and psychiatry on the Case Western Reserve College Faculty of Medication. “Related selections have been made in the UK and Spain, and we hope that different international locations will quickly observe.”
Costa is among the many leaders of a giant and various group of physicians and scientists from seven international locations and greater than a dozen establishments collaborating to review the influence of COVID-19 in folks with Down syndrome, referred to as the T21RS COVID-19 Initiative.
The T21RS COVID-19 Initiative is a part of an effort established in March 2020 by the Trisomy 21 Analysis Society (T21RS) to assemble and disseminate scientific info to help communities of people with Down syndrome and their households internationally throughout the pandemic. The T21RS was based in 2014 and is the world’s largest skilled Down syndrome analysis society.
Supply: Case Western Reserve College
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